Retarded release of small-molecule drugs from phase-separated dextran hydrogels through host-guest complexation

Ki Hyun  Bae; Shengyong Ng; Li Li; Motoichi Kurisawa

doi:10.55092/bm20230002

Technique Report

Open Access

Retarded release of small-molecule drugs from phase-separated dextran hydrogels through host-guest complexation

Ki Hyun Bae¹Shengyong Ng¹Li Li¹Motoichi Kurisawa^1,²^,∗

¹ Institute of Bioengineering and Bioimaging (IBB), Agency for Science, Technology and Research (A*STAR), Singapore

² School of Materials Science, Japan Advanced Institute of Science and Technology, Nomi, Japan

* kurisawa@jaist.ac.jp

Volume
Volume 1 Issue 1, 2023
Citation
Bae KH, Ng S, Li L, Kurisawa M. Retarded release of small-molecule drugs from phase-separated dextran hydrogels through host-guest complexation. Biofunct. Mater. 2023(1):0002, https://doi.org/10.55092/bm20230002.
DOI
10.55092/bm20230002
Copyright
Copyright2023 by the authors. Published by ELSP.

Abstract

Hydrogels have emerged as promising materials for diverse applications in biomedicine and biotechnology, but their use as a drug carrier has been limited by the difficulty of achieving controlled drug release. Herein we report the development of phase-separated dextran hydrogels with 4-arm poly(ethylene glycol)-β-cyclodextrin (4-arm PEG-βCD) microdomains for prolonged release of small-molecule drugs. These hydrogels are designed to enhance the partition of drug molecules in the PEG microdomains through host-guest complexation, leading to delayed drug diffusion through the dextran gel matrix. Three different drugs (β-lapachone, imiquimod and oxaliplatin) were used to investigate the effect of 4-arm PEG-βCD on their partitioning behavior. The mechanical property and microdomain structure of the hydrogels were characterized by oscillatory rheology measurements and confocal laser scanning microscopy, respectively. Interestingly, we observed non-Fickian diffusion phenomena of β-lapachone and imiquimod from the phase-separated hydrogels, suggesting the potential applicability of host-guest interactions for the design of sustained drug release systems.

Keywords

phase separation; dextran; hydrogel; host-guest complexation; drug release

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