Review
Open Access
Exosomes: a potential biomarker and therapeutic targets in diabetic cardiomyopathy
Azhar Anwar1Jizheng Ma2,∗Xin Yin1,3,4,∗
1 Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, Chinese Academy of Medical Sciences Research Unit of Extracellular RNA, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
2 The Research Center of Military Exercise Science, The Army Engineering University of PLA, Nanjing, Jiangsu, China
3 Shenzhen Institute, Peking University, Shenzhen, Guangdong, China
4 Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China
  • Volume
    Volume 6 Issue 3, 2024
  • Citation
    Anwar A, Ma J, Yin X. Exosomes: a potential biomarker and therapeutic targets in diabetic cardiomyopathy. ExRNA 2024(3):0015, https://doi.org/10.55092/exrna20240015. 
  • DOI
    10.55092/exrna20240015
  • Copyright
    Copyright2024 by the authors. Published by ELSP.
Abstract

Diabetic cardiomyopathy (DCM) refers to a complication that arises in diabetic patients and leads to various cardiac dysfunctions. These dysfunctions include oxidative stress, myocardial apoptosis, mitochondrial dysfunction, inflammation, lipotoxicity, fibrosis, impaired Ca2+ handling, and increased fatty acid utilization. Despite significant research efforts, the molecular mechanism underlying DCM remains incompletely understood. Recent studies have highlighted the role of exosomes, which are endogenous nanovesicles, in carrying detrimental components capable of initiating and propagating disease-related signaling events. In this review, we summarize the potential underlying mechanisms of DCM and discuss the potential use of exosomes in understanding the cellular mechanisms involved and exploring therapeutic approaches for DCM. These insights and opportunities may pave the way for new advancements in the field.

Keywords

exosomes; diabetic cardiomyopathy; miRNA

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References
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